Advantage® quickly distributes over the entire body surface of the pet, from the top of the head to the tip of the tail! Within 12 hours of application, Advantage has dried and locked onto the cells on the surface of your pet's skin. This means that the flea can land anywhere on an Advantage-treated pet, and it will still contact enough Advantage to be killed.

Advantage is always present on the skin of treated pet.
Advantage stays on the surface of the pet's skin for four weeks and does not travel systemically in your pet (through its bloodstream or into internal organs). Skin cells go through a natural monthly shed, with old skin cells replaced by new ones. This is why monthly reapplication is necessary.



Advantage spreads over your pet without getting into the bloodstream.
Advantage is lipid or fat soluble, which means that it spreads quickly and is locked onto the oil on the surface of every skin cell. Each skin cell has a lipid or fatty membrane that attracts the lipid soluble Advantage to it. Because Advantage stays on the skin and does not enter the bloodstream, it kills fleas on contact. Fleas do not have to bite the pet or suck blood in order to be killed.

Plus, Advantage is non-systemic and has no cumulative effect, meaning the ingredients will not build up in your pet's body.


How often should Advantage be used?
Use Advantage every month, ideally on the same day of each month. Start as soon as the weather becomes warm depending on your area (April) and continue monthly until well after the first frost (November).


Advantage can be used year round.
Advantage can be applied every month all year round, especially in heavy and constant flea infestation areas of the country.

It's most effective to start using Advantage several weeks prior to the start of flea season (April in most parts of the country) and to continue applying a tube each month until the flea season is over. Advantage is an excellent flea preventative and should be used early in the spring to stop fleas from before they become a problem.


Advantage never expires.
Advantage is heat and light stable. It does not have an expiry date and its efficacy is not affected over time.